Drugs affecting metabolism-

Drugs affecting metabolism-

drug affecting fliud and electrolyte imbalance

1- Restoring water electrolyte  and acid base balance

ex:NaCL .9% --ringer solution(NaCL+KCL+Ca)

these solutions given parenterally in case diarrohea and vomitation (dehydration)

note:excessive fluids should be avoided to avoid water intoxication which cause odema ,haemolysis ,tremors and convulsion

b)glucose solution

5% or 10% solution I/V as source of energy

c)Na lactate

given I/V in sever acidosis

d)Na bicarbonate

in case acidosis

2-Restoring blood volume

a)plasma expander

used when blood or plasma lost as in haemorrage and burning

ex:whole blood :cllected on(anticoagulant) Na citrate 3.8%(1ml Na citrate for 4ml blood) from donor animal and injected to recepient animal at rate 10ml/min

ex:blood plasma:used in shock as in case truma-burning-surgery

b)plasma substitute

ex:dextran - parenteral feeding

3-hormones

a)Aldosterone  :1-reabsorption Na from renal tubules

                         2-Na attracts water with it

b)Deoxycortone acetate

synthetic hormones but weaker than Aldosteron

c)fludrocortisone

synthetic hormone but grater than Aldosteron in activity.

4-diuretics 

5-anti diuretics