Drug affecting carbohydrate metabolism-

Drug affecting carbohydrate metabolism-

synthetic anti hyperglycemics (oral antidiabetic drugs OADs )

mode of action :stimulate insulin release from B cell

1-sulfonylurease as glimepride ,gliclazide ,glibenclamide .

2-meglitinides as phennyl alanine derivatives (natiglinide)

mode of action :anti diabetic action without stimulate insulin release.

1-alpha glucosidase inhibitors as (acarbose )

interfer with glucoseabsorption and digestion

2-biguanides as (metformin)

inhibit liver gluconeogenesis .glycogenolysis and increase peripheral insulin sensitivity

3-thiasolidinediones(glitazones)as(rosiglitazone)

increase sensetivity of tissue to insulin(increase receptor sensetivity)